A special place among gynecological diseases is occupied by menstrual disorders, which manifest as the form of dysmenorrhea in premenopausal women living in the eastern region of Ukraine, where currently active hostilities are taking place.
Analyzing the frequency of gynecological morbidity, it has been determined that 80% of patients have cases of dysmenorrhea, which are accompanied by a deterioration of the general condition of a woman and require appropriate treatment. In contrast to dysmenorrhea, which is caused by a violation of the physiological processes of menstrual function regulation.
Psychogenic factors – acute and chronic stress that lead to neurovegetative and endocrine disorders. That is, it can be noted that the premenopausal period of women is characterized by neuroendocrine-metabolic changes, which in some women do not take on a physiological course. The primary link in the stress response is the central nervous system with the corresponding anxiety-depressive symptoms (sleep disturbances, mood changes, decreased appetite, impaired concentration), which lead to a long-term imbalance in the secretion of neurotransmitters, and therefore, to the hypothalamic-pituitary disorders, under the influence of which anovulatory changes begin in the ovary. All these causes the violation of menstrual function, namely, to a disorder of the ovulation process in the ovary.
Aim and objectives of the study.
To determine the effectiveness of complex therapy using phytoestrogen therapy and herbal sedatives in the treatment of stress-related neurovegetative and psychoemotional disorders in women with dysmenorrhea in premenopausal age.
Materials and research methods.
We examined and studied 29 premenopausal women aged 45–50 years living in the eastern region of Ukraine who had complaints about psychoemotional disorders, which manifested as a form of tearfulness, frequent mood swings, apathy, and menstrual dysfunction in the form of dysmenorrhea, manifested by algodysmenorrhea, opsamenorrhoea, and tachymenorrhea. All patients were divided into 3 clinical groups.
The 1st group consisted of 9 patients with dysmenorrhea who received traditional treatment using hormonal drugs, the 2nd group consisted of 10 patients who underwent a course of phytoestrogen therapy, the third group consisted of 10 women who underwent a complex therapy using phytoestrogen therapy and herbal sedatives. The control group consisted of 10 healthy women.
All patients passed a comprehensive clinical and laboratory examination, determination of hormones in blood serum (FSH, LH, estradiol, progesterone), pelvic ultrasound, and consultation with a gynecologist and psychiatrist.
Results and discussions.
Summing up the results of treatment among patients with dysmenorrhea provoked by stress factors due to military operations, it was identified that a full therapeutic effect with a reduction in all complaints and symptoms that accompanied the development of this pathology was achieved in 4 (44.4%), 7 (70%), and 9 (90%) patients of the 1st, 2nd, and 3rd groups, respectively.
The clinical effectiveness of the complex therapy with the use of phytoestrogen therapy and herbal sedatives in the treatment of patients with dysmenorrhea is confirmed by clinical and laboratory researchs, hormonal and ultrasound studies.
At the same time, all patients in the 2nd and 3d group significantly improved their general well-being, anxiety-depressive symptoms, complaints about pain during menstruation disappeared, and complete normalization of the menstrual cycle and hormone levels was noted: FSH - 5.2±0.2 IU/l, LH - 8.6±1.2 IU/l, estradiol - 112.2±7.5 ng/l, progesterone - 14.4±1.3 ng/l. Studies have also been conducted on the psychosomatic state of patients, which may be due to factors such as the individual psychological characteristics of women and their reaction to stress.
Conclusions.
Therefore the data obtained, diagnostic studies, and consultation with a psychiatrist indicate the absence of mental illness, but there is a connection with the stress factors of this disease in women living in the eastern region of Ukraine, where military operations are taking place, which has proven the high effectiveness of complex therapy in using the phytoestrogen therapy and herbal sedatives, which has proven the absence of side effects and contraindications, can be recommended for widespread use.
Literature.
1. Аyan M., Sogut E., Tas U. et al. Pain levels associated with renal colic and primary dysmenorrhea: a prospective controlled study with objective and subjective outcomes. Arch. Gynecol. Obstet.2012;286: 403-409.
2. Pitangul A.C., Gomes M.R., Lima A.S. et al. Menstruation disturbances: prevalence, characteristics, and effects on the activities of daily living among adolescent girls from Brazil. Gynecol. 2013; 26: 148-152.
3. Eccleston C., Williams A.C. Psychological therapies for the management of chronic pain in adults. Gynecol. 2009; 407.
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